Annick Lesne (Paris):

Complex stochastic dynamics in the modeling of living systems

Abstract:

I will discuss on general grounds some specific aspects of living systems compared to physical ones and the ensuing requirements for their modeling. I will argue that a main specificy of living systems lies in their complex multilevel organization, in which emergent properties exert regulatory feedbacks onto the elements state spaces and rules of evolution. As an illustration, I will detail a scenario of metastasis formation (cancer cells escape from a primary tumor to form a secondary tumor) we recently proposed in collaboration with experimental cell biologists.

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